Contractile and pharmacological properties of rat extraocular muscles.
نویسندگان
چکیده
منابع مشابه
Glucose uptake in rat extraocular muscles: effect of insulin and contractile activity.
PURPOSE Extraocular muscles show specific adaptations to fulfill the metabolic demands imposed by their constant activity. One aspect that has not been explored is the availability of substrate for energy pathways in extraocular muscles. In limb muscles, glucose enters by way of GLUT1 and GLUT4 transporters in a process regulated by insulin and contractile activity to match metabolic supply to ...
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A study has been made of the contractile properties of plantarflexor and dorsiflexor muscles in 25 patients with myotonic dystrophy and in the same number of closely-matched control subjects. As anticipated, the mean torques developed during maximal voluntary contraction and during the isometric twitch were significantly reduced in the patient population, as were the mean amplitudes of the resp...
متن کاملNeurophysiology of extraocular muscles.
E. lye movements may be divided grossly into "tonic" and "phasic" movements. Are both of these principal types produced by the same motor nerves and muscle fibers, or are separate systems present that are functionally suited to each of the types of movements? Morphological and physiological studies demonstrate that at least two and possibly three neuromuscular systems are present in eye muscles...
متن کاملSpecific metabolic properties of rat oculorotatory extraocular muscles can be linked to their low force requirements.
PURPOSE To gain insight into the metabolic pathways of oculorotatory extraocular muscle (EOM) fiber types at the cellular level to explain their high fatigue resistance, rapid contraction, and low force output. METHODS In consecutive sections of adult rat EOMs, the cross-sectional area (CSA) was calculated, and the activities of succinate-dehydrogenase (SDH) and alpha-glycerophosphate dehydro...
متن کاملMitochondria Are Fast Ca Sinks in Rat Extraocular Muscles: A Novel Regulatory Influence on Contractile Function and Metabolism
PURPOSE. The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca concentration ([Ca ]i). Mitochondrial Ca influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca uptake regulates [Ca ]i and production of force in extraocular muscle; (2) mitochondrial content correlates with their use as Ca sinks; and (3) mitoc...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)39358-8